diff --git a/prisma/migrations/0214_v125_physical_clinical_measurements/migration.sql b/prisma/migrations/0214_v125_physical_clinical_measurements/migration.sql
new file mode 100644
index 000000000..3c97dfc7e
--- /dev/null
+++ b/prisma/migrations/0214_v125_physical_clinical_measurements/migration.sql
@@ -0,0 +1,10 @@
+-- v1.25 — clinical-signals wave: physical / clinical measurement types.
+--
+-- Grip strength (EWGSOP2 sarcopenia limb), pain Numeric Rating Scale (0–10),
+-- waist circumference (WHO STEPS), and the waist-to-height ratio (WHtR). Each
+-- is a first-class numeric Measurement type; bands/units are applied at the
+-- display edge from the signal registry. ADD VALUE IF NOT EXISTS is idempotent.
+ALTER TYPE "measurement_type" ADD VALUE IF NOT EXISTS 'GRIP_STRENGTH';
+ALTER TYPE "measurement_type" ADD VALUE IF NOT EXISTS 'PAIN_NRS';
+ALTER TYPE "measurement_type" ADD VALUE IF NOT EXISTS 'WAIST_CIRCUMFERENCE';
+ALTER TYPE "measurement_type" ADD VALUE IF NOT EXISTS 'WAIST_TO_HEIGHT';
diff --git a/prisma/schema.prisma b/prisma/schema.prisma
index abc2d1249..75c095418 100644
--- a/prisma/schema.prisma
+++ b/prisma/schema.prisma
@@ -608,6 +608,7 @@ model User {
   fitbitConnection            FitbitConnection?
   fitbitOAuthStates           FitbitOAuthState[]
   moodEntries                 MoodEntry[]
+  mentalHealthAssessments     MentalHealthAssessment[]
   moodTagsCustom              MoodTag[]                    @relation("UserMoodTags")
   moodTagCategoriesCustom     MoodTagCategory[]            @relation("UserMoodTagCategories")
   moodTagsHidden              MoodTagHidden[]
@@ -1107,10 +1108,90 @@ enum MeasurementType {
   // The 5-level → ordinal mapping is the single source of truth in
   // `src/lib/oura/client.ts` (RESILIENCE_LEVELS). Stored as `source = OURA`.
   RESILIENCE // level (ordinal 1–5) — Oura `daily_resilience.level` (limited=1 … exceptional=5).
+  // ── v1.25 — clinical-signals wave (manual / instrument-derived) ──
+  // PHQ-9 / GAD-7 total scores. Server-derived from a completed
+  // `MentalHealthAssessment` (one measurement row per administration, value =
+  // total). Unit `score`. The raw item answers live encrypted on the
+  // assessment row, never here — these rows carry only the numeric trend so
+  // the existing chart / rollup infra reads them with no item exposure.
+  PHQ9_SCORE // score (0–27) — PHQ-9 depression screen total. Opt-in. See MentalHealthAssessment.
+  GAD7_SCORE // score (0–21) — GAD-7 anxiety screen total. Opt-in. See MentalHealthAssessment.
+  // Maximal isometric handgrip force (best of all trials, either hand). The
+  // EWGSOP2 sarcopenia floor is sex-specific (men < 27 kg, women < 16 kg); the
+  // band is applied at display time, the column stores the raw kg.
+  GRIP_STRENGTH // kg — hand-dynamometer maximal grip (EWGSOP2 sarcopenia limb).
+  // Patient-reported pain intensity on the 0–10 Numeric Rating Scale
+  // (0 = no pain, 10 = worst imaginable). LOINC 72514-3.
+  PAIN_NRS // score (0–10) — pain Numeric Rating Scale.
+  // Waist circumference in cm (WHO STEPS protocol) + the ancestry-robust
+  // waist-to-height ratio (WHtR; keep waist < half your height ⇒ < 0.5).
+  WAIST_CIRCUMFERENCE // cm — waist circumference (WHO bands; ethnicity-aware at display).
+  WAIST_TO_HEIGHT // ratio — waist-to-height ratio (WHtR ≥ 0.5 = increased risk).
 
   @@map("measurement_type")
 }
 
+/// v1.25 — validated mental-health self-assessment instruments: PHQ-9
+/// (depression) + GAD-7 (anxiety). The discriminator on
+/// `MentalHealthAssessment`; extensible (WHO-5 / PSS-10 are natural future
+/// siblings) without a schema change.
+enum AssessmentInstrument {
+  PHQ9
+  GAD7
+
+  @@map("assessment_instrument")
+}
+
+/// v1.25 — one completed administration of a validated mental-health screener
+/// (PHQ-9 / GAD-7). Opt-in, beside the existing `MoodEntry` (never replaces it).
+/// The per-item answers are the most sensitive payload, so they live in a
+/// single AES-256-GCM `Bytes` blob (`responsesEncrypted`) and are never indexed
+/// nor logged. The derived total / band / item-9 flag are denormalised
+/// (server-authoritative) for cheap history reads without decrypting. A
+/// matching `PHQ9_SCORE` / `GAD7_SCORE` Measurement row is written per
+/// administration (linked by `externalId = assessment:<id>`) so the score rides
+/// the existing chart / rollup infra — the trend, never the item content.
+model MentalHealthAssessment {
+  id           String               @id @default(cuid())
+  userId       String               @map("user_id")
+  instrument   AssessmentInstrument
+  /// The validated translation actually presented (officially-validated wording
+  /// per locale, English fallback otherwise — recorded for the audit trail).
+  locale       String
+  /// Instrument variant identifier (e.g. "standard"); future-proofs revisions.
+  version      String               @default("standard")
+  /// Encrypted JSON blob: { items: number[], functionalDifficulty?: 0..3, schema: 1 }.
+  /// AES-256-GCM via the shared Bytes codec; registered in ENCRYPTED_COLUMNS +
+  /// the rotation script. The item-9 raw value lives ONLY here.
+  responsesEncrypted Bytes          @map("responses_encrypted")
+  /// Derived total (PHQ-9 0–27, GAD-7 0–21). Denormalised for fast reads.
+  totalScore   Int                  @map("total_score")
+  /// Derived severity band label (server-authoritative; descriptive, never a diagnosis).
+  severityBand String               @map("severity_band")
+  /// PHQ-9 only: item 9 (self-harm ideation) answered > 0. A coarse boolean so
+  /// the history view can re-surface crisis resources without decrypting.
+  item9Flagged Boolean              @default(false) @map("item9_flagged")
+  /// Audit stamp: the supportive crisis-resource signpost was shown to the user.
+  /// Never triggers any third-party alert — private, on-device-only signposting.
+  crisisShownAt DateTime?           @map("crisis_shown_at")
+  /// Recall-window anchor (when the screener was taken).
+  takenAt      DateTime             @map("taken_at")
+  tz           String?
+  source       String               @default("WEB")
+  externalId   String?              @map("external_id")
+  syncVersion  Int                  @default(0) @map("sync_version")
+  deletedAt    DateTime?            @map("deleted_at")
+  createdAt    DateTime             @default(now()) @map("created_at")
+  updatedAt    DateTime             @updatedAt @map("updated_at")
+
+  user User @relation(fields: [userId], references: [id], onDelete: Cascade)
+
+  @@unique([userId, source, externalId])
+  @@index([userId, instrument, takenAt])
+  @@index([userId, updatedAt, id])
+  @@map("mental_health_assessments")
+}
+
 /// v1.10.0 — categorical events (WX-B)
 /// The device's own classification RESULT / severity for an EVENT row.
 /// Non-NULL only for the categorical EVENT `MeasurementType`s
diff --git a/src/components/measurements/measurement-list-meta.ts b/src/components/measurements/measurement-list-meta.ts
index f27dd5ef2..aabef8a6d 100644
--- a/src/components/measurements/measurement-list-meta.ts
+++ b/src/components/measurements/measurement-list-meta.ts
@@ -122,6 +122,13 @@ export const MEASUREMENT_TYPE_LABEL_KEYS: Record<string, string> = {
   BODY_TEMPERATURE_DEVIATION: "measurements.typeBodyTemperatureDeviation",
   // ── v1.19.0 — Oura resilience ──
   RESILIENCE: "measurements.typeResilience",
+  // ── v1.25 — clinical-signals wave ──
+  PHQ9_SCORE: "measurements.typePhq9Score",
+  GAD7_SCORE: "measurements.typeGad7Score",
+  GRIP_STRENGTH: "measurements.typeGripStrength",
+  PAIN_NRS: "measurements.typePainNrs",
+  WAIST_CIRCUMFERENCE: "measurements.typeWaistCircumference",
+  WAIST_TO_HEIGHT: "measurements.typeWaistToHeight",
 };
 
 export const MEASUREMENT_TYPE_ICONS: Record<string, LucideIcon> = {
@@ -245,6 +252,15 @@ export const MEASUREMENT_TYPE_ICONS: Record<string, LucideIcon> = {
   // Gauge reads as the composite "index / level" dial, matching the other
   // recovery / score composites (RECOVERY_SCORE, DAY_STRAIN).
   RESILIENCE: Gauge,
+  // ── v1.25 — clinical-signals wave ──
+  // Gauge reads as the screener-score dial; Dumbbell carries grip strength;
+  // Activity the pain trace; Scale the anthropometric waist pair.
+  PHQ9_SCORE: Gauge,
+  GAD7_SCORE: Gauge,
+  GRIP_STRENGTH: Dumbbell,
+  PAIN_NRS: Activity,
+  WAIST_CIRCUMFERENCE: Scale,
+  WAIST_TO_HEIGHT: Scale,
 };
 
 export const MEASUREMENT_TYPE_COLORS: Record<string, string> = {
@@ -359,4 +375,13 @@ export const MEASUREMENT_TYPE_COLORS: Record<string, string> = {
   // chart-1 (Dracula purple) marks the derived recovery / score composites as
   // their own visual group, matching RECOVERY_SCORE / DAY_STRAIN.
   RESILIENCE: "bg-chart-1/20 text-chart-1",
+  // ── v1.25 — clinical-signals wave ──
+  // chart-1 (composite/score family) for the screener totals + grip strength;
+  // chart-3 (cardio/alert family) for pain; chart-4 (body family) for waist.
+  PHQ9_SCORE: "bg-chart-1/20 text-chart-1",
+  GAD7_SCORE: "bg-chart-1/20 text-chart-1",
+  GRIP_STRENGTH: "bg-chart-1/20 text-chart-1",
+  PAIN_NRS: "bg-chart-3/20 text-chart-3",
+  WAIST_CIRCUMFERENCE: "bg-chart-4/20 text-chart-4",
+  WAIST_TO_HEIGHT: "bg-chart-4/20 text-chart-4",
 };
diff --git a/src/lib/__tests__/measurement-type-enum-coverage.test.ts b/src/lib/__tests__/measurement-type-enum-coverage.test.ts
index a8ac5ef1c..6f98364cd 100644
--- a/src/lib/__tests__/measurement-type-enum-coverage.test.ts
+++ b/src/lib/__tests__/measurement-type-enum-coverage.test.ts
@@ -98,10 +98,17 @@ const EXPECTED_TYPES = [
   "BODY_TEMPERATURE_DEVIATION",
   // ── v1.19.0 — Oura resilience (ordinal-encoded level) ──
   "RESILIENCE",
+  // ── v1.25 — clinical-signals wave ──
+  "PHQ9_SCORE",
+  "GAD7_SCORE",
+  "GRIP_STRENGTH",
+  "PAIN_NRS",
+  "WAIST_CIRCUMFERENCE",
+  "WAIST_TO_HEIGHT",
 ] as const;
 
 describe("measurementTypeEnum coverage", () => {
-  it("exposes the 67 canonical measurement types", () => {
+  it("exposes the 73 canonical measurement types", () => {
     expect([...measurementTypeEnum.options].sort()).toEqual(
       [...EXPECTED_TYPES].sort(),
     );
@@ -244,6 +251,19 @@ describe("measurementTypeEnum coverage", () => {
     // Insights / measurement-list surfaces and never belongs in the clinical
     // vitals PDF. See doctor-report-pdf-core.ts for the matching rationale.
     "RESILIENCE",
+    // v1.25 — clinical-signals wave. The mental-health screener totals are
+    // opt-in, derived, and deliberately excluded from any export/share/AI
+    // surface by default (item answers are encrypted). The physical clinical
+    // signals (grip strength, pain NRS, waist circumference + WHtR) surface on
+    // their own measurement/insights surfaces; they join the doctor PDF once a
+    // clinical layout + reference ranges land alongside the other v1.5+
+    // additions. See doctor-report-pdf-core.ts for the matching rationale.
+    "PHQ9_SCORE",
+    "GAD7_SCORE",
+    "GRIP_STRENGTH",
+    "PAIN_NRS",
+    "WAIST_CIRCUMFERENCE",
+    "WAIST_TO_HEIGHT",
   ]);
 
   it("doctor-report PDF vital types cover the canonical enum minus documented exclusions", () => {
diff --git a/src/lib/fhir/lab-loinc.ts b/src/lib/fhir/lab-loinc.ts
index 7493cb545..17eaf927f 100644
--- a/src/lib/fhir/lab-loinc.ts
+++ b/src/lib/fhir/lab-loinc.ts
@@ -139,6 +139,36 @@ const LAB_LOINC_BY_KEY: Record<string, LabLoincMapping> = {
     display: "Hemoglobin [Mass/volume] in Blood",
     ucum: "g/dL",
   },
+  // ── v1.25 — longevity lab panel additions (loinc.org confirmed this pass) ──
+  apob: {
+    loinc: "1884-6",
+    display: "Apolipoprotein B [Mass/volume] in Serum or Plasma",
+    ucum: "mg/dL",
+  },
+  lpa: {
+    loinc: "43583-4",
+    display: "Lipoprotein a [Moles/volume] in Serum or Plasma",
+    ucum: "nmol/L",
+  },
+  hscrp: {
+    loinc: "30522-7",
+    display:
+      "C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method",
+    ucum: "mg/L",
+  },
+  ggt: {
+    loinc: "2324-2",
+    display:
+      "Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma",
+    ucum: "U/L",
+  },
+  fastinginsulin: {
+    loinc: "27873-9",
+    display: "Insulin [Units/volume] in Serum or Plasma --fasting",
+    ucum: "u[IU]/mL",
+  },
+  // NOTE(NEEDS-VERIFY): the RBC omega-3 index has no confirmed LOINC this pass
+  // — it intentionally falls back to a local text-only concept on export.
 };
 
 /**
@@ -206,6 +236,20 @@ const LAB_ALIASES: Record<string, string> = {
   hb: "hemoglobin",
   hgb: "hemoglobin",
   hamoglobin: "hemoglobin",
+  // ── v1.25 — longevity lab panel aliases ──
+  apolipoproteinb: "apob",
+  apolipoprotein: "apob",
+  lipoproteina: "lpa",
+  lpkleina: "lpa",
+  hscrp: "hscrp",
+  highsensitivitycrp: "hscrp",
+  hochsensitivescrp: "hscrp",
+  gammagt: "ggt",
+  gammaglutamyltransferase: "ggt",
+  ggtp: "ggt",
+  fastinginsulin: "fastinginsulin",
+  insulinfasting: "fastinginsulin",
+  nuchterninsulin: "fastinginsulin",
 };
 
 /**
diff --git a/src/lib/fhir/loinc-map.ts b/src/lib/fhir/loinc-map.ts
index 31c9324cb..814ca0558 100644
--- a/src/lib/fhir/loinc-map.ts
+++ b/src/lib/fhir/loinc-map.ts
@@ -23,7 +23,14 @@ export const UCUM_SYSTEM = "http://unitsofmeasure.org";
 export const HEALTHKIT_CODESYSTEM =
   "https://healthlog.dev/fhir/CodeSystem/healthkit";
 
-export type FhirObservationCategory = "vital-signs" | "laboratory" | "activity";
+export type FhirObservationCategory =
+  | "vital-signs"
+  | "laboratory"
+  | "activity"
+  // v1.25 — patient-reported screener / questionnaire observations (PHQ-9 /
+  // GAD-7 totals, pain NRS). The builder already emits a `survey` category for
+  // the descriptive wellness composites; `categoryConcept` takes any string.
+  | "survey";
 
 export interface LoincMapping {
   /** LOINC code, or null when no stable LOINC applies (local text fallback). */
diff --git a/src/lib/labs/__tests__/homa-ir.test.ts b/src/lib/labs/__tests__/homa-ir.test.ts
new file mode 100644
index 000000000..205827936
--- /dev/null
+++ b/src/lib/labs/__tests__/homa-ir.test.ts
@@ -0,0 +1,33 @@
+import { describe, it, expect } from "vitest";
+import { computeHomaIr, classifyHomaIr } from "@/lib/labs/homa-ir";
+
+describe("computeHomaIr", () => {
+  it("computes the conventional-unit formula (glucose × insulin ÷ 405)", () => {
+    // 90 mg/dL × 5 µIU/mL ÷ 405 = 1.111…
+    expect(computeHomaIr(90, 5)).toBeCloseTo(1.1111, 3);
+  });
+
+  it("matches the SI form within rounding (mmol/L × insulin ÷ 22.5)", () => {
+    // 100 mg/dL = 5.556 mmol/L; SI: 5.556 × 8 ÷ 22.5 ≈ 1.975; conv: 100×8÷405 ≈ 1.975
+    const conv = computeHomaIr(100, 8)!;
+    const si = (5.5556 * 8) / 22.5;
+    expect(conv).toBeCloseTo(si, 2);
+  });
+
+  it("returns null for missing or non-positive inputs", () => {
+    expect(computeHomaIr(null, 5)).toBeNull();
+    expect(computeHomaIr(90, undefined)).toBeNull();
+    expect(computeHomaIr(0, 5)).toBeNull();
+    expect(computeHomaIr(90, -1)).toBeNull();
+    expect(computeHomaIr(Number.NaN, 5)).toBeNull();
+  });
+});
+
+describe("classifyHomaIr", () => {
+  it("places values in the documented bands", () => {
+    expect(classifyHomaIr(0.8)).toBe("optimal");
+    expect(classifyHomaIr(1.5)).toBe("intermediate");
+    expect(classifyHomaIr(2.5)).toBe("elevated");
+    expect(classifyHomaIr(3.5)).toBe("high");
+  });
+});
diff --git a/src/lib/labs/biomarker-catalog.ts b/src/lib/labs/biomarker-catalog.ts
index 3771d4a88..6b33f8569 100644
--- a/src/lib/labs/biomarker-catalog.ts
+++ b/src/lib/labs/biomarker-catalog.ts
@@ -61,6 +61,33 @@ export const BIOMARKER_CATALOG: readonly BiomarkerSeed[] = [
     lowerBound: null,
     upperBound: 150,
   },
+  // v1.25 — longevity panel: atherogenic-particle burden + genetic + RBC EPA/DHA.
+  // ApoB is the primary atherogenic-burden number (ESC/EAS 2019); the upper
+  // bound is the population-desirable line, lower goals are care-context-specific.
+  {
+    slug: "apob",
+    panel: "lipids",
+    unit: "mg/dL",
+    lowerBound: null,
+    upperBound: 90,
+  },
+  // Lp(a) is largely genetically fixed (measure once, flag elevated); molar
+  // (nmol/L) reporting preferred — never interconvert mass↔molar by a factor.
+  {
+    slug: "lp-a",
+    panel: "lipids",
+    unit: "nmol/L",
+    lowerBound: null,
+    upperBound: 125,
+  },
+  // Omega-3 index (RBC EPA+DHA %): cardioprotective/optimal 8–12%.
+  {
+    slug: "omega-3-index",
+    panel: "lipids",
+    unit: "%",
+    lowerBound: 8,
+    upperBound: null,
+  },
   // Glucose metabolism
   {
     slug: "fasting-glucose",
@@ -76,6 +103,16 @@ export const BIOMARKER_CATALOG: readonly BiomarkerSeed[] = [
     lowerBound: null,
     upperBound: 5.7,
   },
+  // v1.25 — longevity panel: fasting insulin (metabolically-optimal often
+  // cited < 8 µIU/mL; typical reference ~2.5–13). HOMA-IR is derived from
+  // fasting glucose × insulin (see `homa-ir.ts`), not a stored catalog marker.
+  {
+    slug: "fasting-insulin",
+    panel: "glucose",
+    unit: "µIU/mL",
+    lowerBound: 2.5,
+    upperBound: 13,
+  },
   // Thyroid
   {
     slug: "tsh",
diff --git a/src/lib/labs/homa-ir.ts b/src/lib/labs/homa-ir.ts
new file mode 100644
index 000000000..289f15e9d
--- /dev/null
+++ b/src/lib/labs/homa-ir.ts
@@ -0,0 +1,47 @@
+/**
+ * v1.25 — HOMA-IR (Homeostatic Model Assessment of Insulin Resistance).
+ *
+ * A computed longevity marker derived from fasting glucose + fasting insulin —
+ * NOT a stored biomarker catalog entry (BMI's derived-value precedent). Server-
+ * authoritative per the parity rule: compute it here, never recompute on the
+ * client. Pure + side-effect-free so it is trivially testable.
+ *
+ * Conventional-unit formula (fasting glucose mg/dL × fasting insulin µIU/mL ÷
+ * 405) and the SI form (mmol/L × µIU/mL ÷ 22.5) are equivalent
+ * (mg/dL ÷ 18 = mmol/L; 405 = 22.5 × 18). Population-dependent interpretive
+ * bands (optimal < 1.0, early IR > 1.9, significant IR > 2.9) are applied at the
+ * display edge, never asserted here. [HOMA-IR, PMC5033570].
+ */
+
+/** Interpretive band for a HOMA-IR index value (population-dependent guidance). */
+export type HomaIrBand = "optimal" | "intermediate" | "elevated" | "high";
+
+/**
+ * Compute HOMA-IR from fasting glucose (mg/dL) and fasting insulin (µIU/mL).
+ * Returns `null` when either input is missing or non-positive (the index is
+ * undefined for a zero/negative reading).
+ */
+export function computeHomaIr(
+  fastingGlucoseMgDl: number | null | undefined,
+  fastingInsulinUiuMl: number | null | undefined,
+): number | null {
+  if (
+    fastingGlucoseMgDl == null ||
+    fastingInsulinUiuMl == null ||
+    !Number.isFinite(fastingGlucoseMgDl) ||
+    !Number.isFinite(fastingInsulinUiuMl) ||
+    fastingGlucoseMgDl <= 0 ||
+    fastingInsulinUiuMl <= 0
+  ) {
+    return null;
+  }
+  return (fastingGlucoseMgDl * fastingInsulinUiuMl) / 405;
+}
+
+/** Place a HOMA-IR value in its descriptive band (general guidance, not a diagnosis). */
+export function classifyHomaIr(value: number): HomaIrBand {
+  if (value < 1.0) return "optimal";
+  if (value <= 1.9) return "intermediate";
+  if (value <= 2.9) return "elevated";
+  return "high";
+}
diff --git a/src/lib/measurements/categories.ts b/src/lib/measurements/categories.ts
index f9457adf2..b9065d0a2 100644
--- a/src/lib/measurements/categories.ts
+++ b/src/lib/measurements/categories.ts
@@ -204,6 +204,18 @@ export const MEASUREMENT_CATEGORIES: ReadonlyMap<
   // The resilience level is a derived recovery composite (ordinal-encoded
   // band) → scores cluster alongside RECOVERY_SCORE / ANS_CHARGE.
   ["RESILIENCE", "scores"],
+
+  // ── v1.25 — clinical-signals wave ──
+  // PHQ-9 / GAD-7 totals are composite screener indices → scores cluster.
+  ["PHQ9_SCORE", "scores"],
+  ["GAD7_SCORE", "scores"],
+  // Grip strength is a strength/fitness reading → activity cluster.
+  ["GRIP_STRENGTH", "activity"],
+  // Pain NRS is a patient-reported clinical point-in-time signal → vitals.
+  ["PAIN_NRS", "vitals"],
+  // Waist circumference + waist-to-height are anthropometric → body cluster.
+  ["WAIST_CIRCUMFERENCE", "body"],
+  ["WAIST_TO_HEIGHT", "body"],
 ]);
 
 /**
diff --git a/src/lib/personal-records/pr-direction.ts b/src/lib/personal-records/pr-direction.ts
index 0058a5131..097905945 100644
--- a/src/lib/personal-records/pr-direction.ts
+++ b/src/lib/personal-records/pr-direction.ts
@@ -77,6 +77,9 @@ export function getPRDirection(
     case "SIX_MINUTE_WALK_DISTANCE":
     case "STAIR_ASCENT_SPEED":
     case "STAIR_DESCENT_SPEED":
+    // v1.25 — grip strength is a clean strength-achievement axis (higher is the
+    // record), the strength limb of the EWGSOP2 sarcopenia algorithm.
+    case "GRIP_STRENGTH":
       return PersonalRecordDirection.MAX;
 
     // MIN direction — lower value is the record.
@@ -194,6 +197,17 @@ export function getPRDirection(
     // inputs — a derived composite with no clean goal axis, so it stays null
     // like the other device-derived scores.
     case "RESILIENCE":
+    // v1.25 — clinical-signals wave. The mental-health screener totals are
+    // deliberately NOT gamified (no streaks / "best score" framing around a
+    // depression / anxiety screen — research safety rule). Pain NRS is a
+    // symptom, not an achievement axis. Waist circumference + waist-to-height
+    // are goal-dependent like WEIGHT (a lower waist is a goal for some, not
+    // all). All defer to a null PR direction.
+    case "PHQ9_SCORE":
+    case "GAD7_SCORE":
+    case "PAIN_NRS":
+    case "WAIST_CIRCUMFERENCE":
+    case "WAIST_TO_HEIGHT":
       return null;
   }
 }
diff --git a/src/lib/signals/__tests__/fixtures/expected-measurement-loinc.json b/src/lib/signals/__tests__/fixtures/expected-measurement-loinc.json
index ef811a6a1..19cd326e6 100644
--- a/src/lib/signals/__tests__/fixtures/expected-measurement-loinc.json
+++ b/src/lib/signals/__tests__/fixtures/expected-measurement-loinc.json
@@ -214,5 +214,41 @@
     "display": "Sleeping breathing disturbances",
     "unit": "{count}",
     "category": "vital-signs"
+  },
+  "PHQ9_SCORE": {
+    "loinc": "44261-6",
+    "display": "Patient Health Questionnaire 9 item (PHQ-9) total score [Reported]",
+    "unit": "{score}",
+    "category": "survey"
+  },
+  "GAD7_SCORE": {
+    "loinc": "70274-6",
+    "display": "Generalized anxiety disorder 7 item (GAD-7) total score [Reported.PHQ]",
+    "unit": "{score}",
+    "category": "survey"
+  },
+  "GRIP_STRENGTH": {
+    "loinc": null,
+    "display": "Hand grip strength",
+    "unit": "kg",
+    "category": "vital-signs"
+  },
+  "PAIN_NRS": {
+    "loinc": "72514-3",
+    "display": "Pain severity - 0-10 verbal numeric rating [Score] - Reported",
+    "unit": "{score}",
+    "category": "survey"
+  },
+  "WAIST_CIRCUMFERENCE": {
+    "loinc": "8280-0",
+    "display": "Waist circumference at umbilicus by Tape measure",
+    "unit": "cm",
+    "category": "vital-signs"
+  },
+  "WAIST_TO_HEIGHT": {
+    "loinc": null,
+    "display": "Waist to height ratio",
+    "unit": "1",
+    "category": "vital-signs"
   }
 }
diff --git a/src/lib/signals/registry.ts b/src/lib/signals/registry.ts
index 4f26dda81..cbb4f5948 100644
--- a/src/lib/signals/registry.ts
+++ b/src/lib/signals/registry.ts
@@ -1199,6 +1199,310 @@ export const SIGNALS: Record<string, SignalDefinition> = {
       mcp: true,
     },
   },
+  // ── v1.25 clinical-signals wave — validated mental-health screeners ──────
+  // PHQ-9 / GAD-7 totals. Opt-in, beside mood tracking. Deliberately kept OFF
+  // the Coach snapshot + MCP surfaces (`coachSnapshot:false` ⇒ `mcp:false`):
+  // mental-health item content is excluded from AI by construction, and the
+  // score trend stays a quiet local signal. FHIR rides the `survey` category
+  // with the instrument total-score LOINC.
+  PHQ9_SCORE: {
+    key: "PHQ9_SCORE",
+    kind: "score",
+    source: { measurementType: "PHQ9_SCORE" },
+    displayName: "PHQ-9 depression screen (total)",
+    unit: "score",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    normalRange: { low: 0, high: 4 },
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+    fhir: {
+      loinc: "44261-6",
+      display: "Patient Health Questionnaire 9 item (PHQ-9) total score [Reported]",
+      unit: "{score}",
+      category: "survey",
+    },
+  },
+  GAD7_SCORE: {
+    key: "GAD7_SCORE",
+    kind: "score",
+    source: { measurementType: "GAD7_SCORE" },
+    displayName: "GAD-7 anxiety screen (total)",
+    unit: "score",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    normalRange: { low: 0, high: 4 },
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+    fhir: {
+      loinc: "70274-6",
+      display:
+        "Generalized anxiety disorder 7 item (GAD-7) total score [Reported.PHQ]",
+      unit: "{score}",
+      category: "survey",
+    },
+  },
+  // ── v1.25 clinical-signals wave — physical / clinical measurements ──────
+  GRIP_STRENGTH: {
+    key: "GRIP_STRENGTH",
+    kind: "measurement",
+    source: { measurementType: "GRIP_STRENGTH" },
+    displayName: "Grip strength",
+    unit: "kg",
+    direction: "higher-better",
+    archetype: "activity-fitness",
+    // Coarse population floor; the EWGSOP2 cut-off is sex-specific (men < 27,
+    // women < 16 kg) and applied at the display edge.
+    normalRange: { low: 16, high: 60 },
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+    fhir: {
+      // TODO(NEEDS-VERIFY): no hand-grip-strength LOINC confirmed this pass —
+      // emits a local text concept until a stable LOINC is checked on loinc.org.
+      loinc: null,
+      display: "Hand grip strength",
+      unit: "kg",
+      category: "vital-signs",
+    },
+  },
+  PAIN_NRS: {
+    key: "PAIN_NRS",
+    kind: "measurement",
+    source: { measurementType: "PAIN_NRS" },
+    displayName: "Pain (0–10 NRS)",
+    unit: "score",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    normalRange: { low: 0, high: 3 },
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+    fhir: {
+      loinc: "72514-3",
+      display: "Pain severity - 0-10 verbal numeric rating [Score] - Reported",
+      unit: "{score}",
+      category: "survey",
+    },
+  },
+  WAIST_CIRCUMFERENCE: {
+    key: "WAIST_CIRCUMFERENCE",
+    kind: "measurement",
+    source: { measurementType: "WAIST_CIRCUMFERENCE" },
+    sourcePriorityKey: "waist",
+    displayName: "Waist circumference",
+    unit: "cm",
+    direction: "lower-better",
+    archetype: "body-composition",
+    // WHO European-origin increased-risk threshold (men > 94); ethnicity-aware
+    // bands are applied at the display edge.
+    normalRange: { low: 0, high: 94 },
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+    fhir: {
+      loinc: "8280-0",
+      display: "Waist circumference at umbilicus by Tape measure",
+      unit: "cm",
+      category: "vital-signs",
+    },
+  },
+  WAIST_TO_HEIGHT: {
+    key: "WAIST_TO_HEIGHT",
+    kind: "measurement",
+    source: { measurementType: "WAIST_TO_HEIGHT" },
+    displayName: "Waist-to-height ratio",
+    unit: "ratio",
+    direction: "lower-better",
+    archetype: "body-composition",
+    // NICE: keep waist under half your height — WHtR ≥ 0.5 flags increased risk.
+    normalRange: { low: 0, high: 0.5 },
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+    fhir: {
+      // TODO(NEEDS-VERIFY): WHtR LOINC not confirmed this pass — local text concept.
+      loinc: null,
+      display: "Waist to height ratio",
+      unit: "1",
+      category: "vital-signs",
+    },
+  },
+  // ── v1.25 clinical-signals wave — longevity lab panel (kind:"biomarker") ─
+  // Registered through the registry to prove the labs path under one definition
+  // shape. The lab FHIR/UCUM coding lives in `fhir/lab-loinc.ts`; the
+  // biomarker-detail rail renders these via the labs catalog. Off Coach/MCP
+  // here (the labs surface has its own `get_labs` MCP tool).
+  APOB: {
+    key: "APOB",
+    kind: "biomarker",
+    source: { biomarkerKey: "apob" },
+    displayName: "Apolipoprotein B",
+    unit: "mg/dL",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  LPA: {
+    key: "LPA",
+    kind: "biomarker",
+    source: { biomarkerKey: "lp-a" },
+    displayName: "Lipoprotein(a)",
+    unit: "nmol/L",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  HS_CRP: {
+    key: "HS_CRP",
+    kind: "biomarker",
+    source: { biomarkerKey: "hs-crp" },
+    displayName: "hs-CRP",
+    unit: "mg/L",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  HBA1C: {
+    key: "HBA1C",
+    kind: "biomarker",
+    source: { biomarkerKey: "hba1c" },
+    displayName: "HbA1c",
+    unit: "%",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  FASTING_GLUCOSE: {
+    key: "FASTING_GLUCOSE",
+    kind: "biomarker",
+    source: { biomarkerKey: "fasting-glucose" },
+    displayName: "Fasting glucose",
+    unit: "mg/dL",
+    direction: "target-band",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  FASTING_INSULIN: {
+    key: "FASTING_INSULIN",
+    kind: "biomarker",
+    source: { biomarkerKey: "fasting-insulin" },
+    displayName: "Fasting insulin",
+    unit: "µIU/mL",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  EGFR: {
+    key: "EGFR",
+    kind: "biomarker",
+    source: { biomarkerKey: "egfr" },
+    displayName: "eGFR (CKD-EPI 2021)",
+    unit: "mL/min/1.73m²",
+    direction: "higher-better",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  GGT: {
+    key: "GGT",
+    kind: "biomarker",
+    source: { biomarkerKey: "ggt" },
+    displayName: "GGT",
+    unit: "U/L",
+    direction: "lower-better",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  FERRITIN: {
+    key: "FERRITIN",
+    kind: "biomarker",
+    source: { biomarkerKey: "ferritin" },
+    displayName: "Ferritin",
+    unit: "ng/mL",
+    direction: "target-band",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
+  OMEGA3_INDEX: {
+    key: "OMEGA3_INDEX",
+    kind: "biomarker",
+    source: { biomarkerKey: "omega-3-index" },
+    displayName: "Omega-3 index",
+    unit: "%",
+    direction: "higher-better",
+    archetype: "physiological-vital",
+    surfaces: {
+      detailPage: false,
+      correlationEligible: false,
+      coachSnapshot: false,
+      mcp: false,
+    },
+  },
 };
 
 /** Type guard: narrow an arbitrary string to a registered signal key. */
diff --git a/src/lib/validations/measurement.ts b/src/lib/validations/measurement.ts
index 2c11ba6f0..f8fc675f2 100644
--- a/src/lib/validations/measurement.ts
+++ b/src/lib/validations/measurement.ts
@@ -122,6 +122,19 @@ export const measurementTypeEnum = z.enum([
   // into the numeric value (limited=1 … exceptional=5), unit `level`. Ingests
   // server-side as `source = OURA`. See `RESILIENCE_LEVELS` in `src/lib/oura/client`.
   "RESILIENCE",
+  // ── v1.25 — clinical-signals wave ──
+  // PHQ-9 / GAD-7 derived total scores (one row per completed administration;
+  // value = total). The raw item answers never ride a Measurement row — they
+  // stay in the encrypted MentalHealthAssessment blob.
+  "PHQ9_SCORE",
+  "GAD7_SCORE",
+  // Grip strength (kg), pain Numeric Rating Scale (0–10), waist circumference
+  // (cm) + waist-to-height ratio. First-class numeric clinical signals; bands
+  // applied at the display edge from the signal registry.
+  "GRIP_STRENGTH",
+  "PAIN_NRS",
+  "WAIST_CIRCUMFERENCE",
+  "WAIST_TO_HEIGHT",
 ]);
 
 /**
@@ -357,6 +370,13 @@ const unitMap: Record<string, string> = {
   // Ordinal level scale (1=limited … 5=exceptional) — the categorical band
   // encoded into the numeric value. See RESILIENCE_LEVELS in src/lib/oura/client.
   RESILIENCE: "level",
+  // ── v1.25 — clinical-signals wave ──
+  PHQ9_SCORE: "score",
+  GAD7_SCORE: "score",
+  GRIP_STRENGTH: "kg",
+  PAIN_NRS: "score",
+  WAIST_CIRCUMFERENCE: "cm",
+  WAIST_TO_HEIGHT: "ratio",
 };
 
 export function getUnitForType(type: string): string {
@@ -551,6 +571,20 @@ export const VALUE_RANGES: Record<string, { min: number; max: number }> = {
   // Ordinal level scale: 1 (limited) … 5 (exceptional). The closed encoding
   // never falls outside this band.
   RESILIENCE: { min: 1, max: 5 },
+  // ── v1.25 — clinical-signals wave ──
+  // PHQ-9 total 0–27, GAD-7 total 0–21 — server-derived from the screener.
+  PHQ9_SCORE: { min: 0, max: 27 },
+  GAD7_SCORE: { min: 0, max: 21 },
+  // Grip strength kg — a child can read in the single digits, an elite athlete
+  // tops ~90 kg; 120 is a generous ceiling that still rejects sensor noise.
+  GRIP_STRENGTH: { min: 0, max: 120 },
+  // Pain NRS — the validated 0–10 scale; the closed band pins the integer.
+  PAIN_NRS: { min: 0, max: 10 },
+  // Waist circumference cm — paediatric lows ~30, severe obesity ~250.
+  WAIST_CIRCUMFERENCE: { min: 30, max: 250 },
+  // Waist-to-height ratio — dimensionless; healthy ~0.4–0.5, the band is
+  // generous either side to admit any plausible body habitus.
+  WAIST_TO_HEIGHT: { min: 0.2, max: 1.5 },
 };
 
 export function validateMeasurementRange(